
- Episode 1 Julie Bowen / Jonathan Winters / Priscilla Ahn
- Episode 2 Katey Sagal / Nathan Fillion
- Episode 3 Julie Chen / Maria Bello / Shelby Lynne
- Episode 4 Eva Longoria / Neal McDonough
- Episode 5 Kal Penn / Gabe Dixon Band
- Episode 6 Julie Chen / Neil Patrick Harris / Sophia Myles Craig welcomes TV host Julie Chen for a "Big Brother" update, actor Neil Patrick Harris and actress Sophia Myles.
- Episode 7 Russell Brand / Margaret Cho
- Episode 8 Alice Cooper / AnnaLynne McCord
- Episode 9 Lynn Ferguson / Lance Morrow Craig welcomes his sister, actress Lynn Ferguson and author Lance Morrow.
- Episode 10 Seann William Scott / Lena Heady Craig welcomes actress Lena Heady. Sean William Scott is stuck in traffic, so he welcomes segment producer Lisa Ammerman instead.
- Episode 11 Julie Chen / Jason Biggs / The Ting Tings
- Episode 12 Paulina Porizkova / Ken Tucker / Tally Hall
- Episode 13 Alan Alda / Illeana Douglas
- Episode 14 Jason Segel / Dr Dog / Steve Hofstetter
- Episode 15 Kristen Bell / Josh Radnor Craig welcomes actress Kristen Bell, actor Josh Radnor. With special feature of "Murder, She Wrote" with Samuel L. Jackson.
- Episode 16 Denis Leary / Marianne Jean-Baptiste
- Episode 17 John Krasinski / Lisa Masterson
- Episode 18 Michael Clarke Duncan / Shirley Manson / Jamie Lidell
- Episode 19 Tim Gunn / Elizabeth Reaser
- Episode 20 Drew Carey / Tony Parker / Lady Antebellum
- Episode 21 Melina Kanakaredes / Gina Carano / Amy Macdonald
- Episode 22 Tim Daly / Anna Friel / Alice Cooper
- Episode 23 Jennifer Love Hewitt / Jim Parsons
- Episode 24 Lauren Graham / Patrick Pedraja / Michael Franti & Spearhead
- Episode 25 Margaret Cho / Randy Newman / Randy Newman
- Episode 26 Seth Green / Betty White / Smothers Brothers
- Episode 27 Thandie Newton / Barry Sonnenfeld / Jim Bianco Craig welcomes actress Thandie Newton and director Barry Sonnenfeld. Musical Guest Jim Bianco performs "I Got A Thing For You".
- Episode 28 Rufus Sewell / Natasha Bedingfield
- Episode 29 Russell Crowe / Jennifer Esposito
- Episode 30 Matt Lucas & David Walliams / Tom Morello
- Episode 31 Dee Dee Myers / Noah Emmerich
- Episode 32 Rachael Ray / Leanne Marshall / Laura Marling
- Episode 33 Chris Matthews / Christopher Mintz-Plasse
- Episode 34 John Malkovich / Little Jackie
- Episode 35 Mo’Nique / Bill Santiago / Lenka
- Episode 36 Kathy Griffin / Carl Bernstein
- Episode 37 Pepe the King Prawn / Saffron Burrows
- Episode 38 Ben Stein / Parminder Nagra / The New York Dolls
- Episode 39 Kevin Smith / Kaitlin Olson
- Episode 40 Lauren Graham / The Damned
- Episode 41 Bill Maher
- Episode 42 Paris Hilton / Drew Pinsky
- Episode 43 Elizabeth Banks / Jay Mohr
- Episode 44 Christian Slater / Luke Dempsey / Eric Hutchinson
- Episode 45 Mark Harmon / Ron White
- Episode 46 Coolio / Tom Dreesen / Tim Reid
- Episode 47 Seann William Scott / Kathy Kinney
- Episode 48 Andy Richter / Cold War Kids
- Episode 49 Jim Parsons / Ray Davies
- Episode 50 Poppy Montgomery / Nick Hornby
- Episode 51 Steve Harvey / Sarah Shahi / The Bacon Brothers
- Episode 52 James Lipton / Sara Gilbert / Sarah McLachlan
- Episode 53 Larry the Cable Guy / Third Day
- Episode 54 George Hamilton / Cobie Smulders
- Episode 55 Eamonn Walker / Low vs Diamond
- Episode 56 Neil Patrick Harris / Julia Fordham
- Episode 57 Adam Arkin / Jen Kirkman / Adele
- Episode 58 Tony Curtis / Megalyn Echikunwoke / Oppenheimer
- Episode 59 Kristin Chenoweth / Diedrich Bader Craig welcomes actress Kristin Chenoweth and actor Diedrich Bader. Kristin Chenoweth performs "I'll Be Home For Christmas".
- Episode 60 Chi McBride / Seal
- Episode 61 Elizabeth Banks / Ken Tucker
- Episode 62 Alfred Molina / Tokyo Police Club
- Episode 63 Brooke Shields / Dom Irrera
- Episode 64 Carrie Fisher / Julie Benz Craig welcomes actresses Carrie Fisher and Julie Benz.
- Episode 65 Carmen Electra / Dennis Lehane
- Episode 66 Don Rickles / Joanna Garcia
- Episode 67 Samuel L. Jackson / Death Cab for Cutie
- Episode 68 Julia Ormond / Michael Connelly
- Episode 69 Jeffrey Tambor / Patrick Keane
- Episode 70 Joel McHale / Matt Nathanson
- Episode 71 Billy Bob Thornton / Conor Oberst Craig welcomes actor Billy Bob Thornton, Conor Oberst performs "Cape Canaveral". Special Guest Tom Arnold stops by.
- Episode 72 Kristen Bell / Wolfgang Puck
- Episode 73 Richard Lewis / Tracie Thoms
- Episode 74 Marisa Tomei / Pauley Perrette
- Episode 75 William Shatner / Jazmine Sullivan
- Episode 76 Amy Sedaris / Dennis Haysbert
- Episode 77 Ted Danson / Paula Poundstone
- Episode 78 John Corbett / Tracie Thoms
- Episode 79 Kristin Scott Thomas / Josh Jackson
- Episode 80 John Waters / Norah O’Donnell
- Episode 81 Wanda Sykes / Glasvegas
- Episode 82 Dev Patel / Greg Proops
- Episode 83 Sarah Chalke / Jeffrey Dean Morgan / Seal
- Episode 84 Joel McHale / The Submarines
- Episode 85 Trace Adkins / Perez Hilton
- Episode 86 Jennifer Love Hewitt / Matthew Rhys
- Episode 87 James Earl Jones / Rosemarie DeWitt
- Episode 88 Chris Matthews / Paul Morrissey
- Episode 89 RZA / Jared Harris
- Episode 90 Cuba Gooding Jr. / Freida Pinto Craig welcomes actor Cuba Gooding Jr., actress Freida Pinto and Special Guest Henry Winkler.
- Episode 91 Dominic Monaghan / Rosemarie DeWitt
- Episode 92 Michael Sheen / Russell Peters / Sharon Jones & The Dap-Kings
- Episode 93 Alfred Molina / Lance Burton Craig welcomes actor Alfred Molina and in this first show of "Magic Week" magician Lance Burton, introduced by Neil Patrick Harris. Features a special segment of "ESPN UK".
- Episode 94 Robin Williams / Jason Randal In the second night of "Magic Week", Craig welcomes actor Robin Williams and magician Jason Randal, introduced by Neil Patrick Harris.
- Episode 95 Samuel L. Jackson / Jason Hudy As "Magic Week" continues, Craig welcomes actor Samuel L. Jackson and magician Jason Hudy, introduced by Neil Patrick Harris.
- Episode 96 Garry Shandling / Ed Alonzo In this Episode of "Magic Week", the roof is leaky and Craig welcomes comedian Garry Shandling as well as magician Ed Alonzo, introduced by Neil Patrick Harris.
- Episode 97 Kristen Bell / Franz Ferdinand In the final show of "Magic Week", Craig welcomes actress Kristen Bell and musician Alex Kapranos. He later performs magic with the help of Kristen Bell and "Marguerite" (Ed Alonzo).…
- Episode 98 Michael Clarke Duncan / Richard Zoglin / Adele
- Episode 99 Sean Combs / Olivia Williams
- Episode 100 Steve Coogan / Connie Britton
- Episode 101 Lewis Black / Shirley Manson
- Episode 102 Tom Selleck / Glen Campbell
- Episode 103 David Boreanaz / Philip Johnson / Zac Brown Band
- Episode 104 Bill Maher / Chris Klein Craig welcomes comedian Bill Maher and actor Chris Klein.
- Episode 105 Wynonna / Peter Bart
- Episode 106 Paula Abdul / Carl Edwards
- Episode 107 Rosie O’Donnell / The Knux
- Episode 108 Paris Hilton / Dee Dee Myers
- Episode 109 Kristin Davis / Wolfgang Puck
- Episode 110 Desmond Tutu Craig welcomes Archbishop Desmond Tutu.
- Episode 111 Holly Hunter / Andrew Bird
- Episode 112 Amy Adams / M Ward / Nick Griffin
- Episode 113 Jason Segel / Dave Attell
- Episode 114 Rosario / Gordon Ramsay
- Episode 115 Tim Daly / Kara Cooney
- Episode 116 Jim Parsons / Sara Bareilles
- Episode 117 Christina Ricci / Mike Birbiglia
- Episode 118 Regis Philbin / The Upper Crust
- Episode 119 Julia Louis-Dreyfus / Dropkick Murphys
- Episode 120 Steven Wright / Rashida Jones
- Episode 121 Paul Rudd / George Wallace
- Episode 122 Virginia Madsen / Jason Ritter / Chicago
- Episode 123 Jerry O’Connell / Tucker Albrizzi / Patrick Pedraja / Ra Ra Riot
- Episode 124 William Shatner / Regina King
- Episode 125 Isabella Rossellini / Linda Cardellini Craig welcomes actresses Isabella Rosselini and Linda Cardellini. Also appearing: comedian Steven Wright.
- Episode 126 Jennifer Tilly / Heidi Newfield
- Episode 127 Brittany Murphy / Christopher Gorham
- Episode 128 Zooey Deschanel / Lance Krall
- Episode 129 Dwight Yoakam / Mary McCormack Craig welcomes musician Dwight Yoakam and actress Mary McCormack.
- Episode 130 Adam Goldberg / Anna Gunn / Brett Dennen
- Episode 131 Michael Caine / Matt Beatz
- Episode 132 Madeleine Albright / Amy Smart
- Episode 133 Jessica Lange / Tom Lennon / Madeleine Peyroux
- Episode 134 Simon Cowell / Jean Smart / Erin McCarley
- Episode 135 Rob Morrow / Jean-Michel Cousteau
- Episode 136 Bob Barker / Jean Smart
- Episode 137 Teri Hatcher / Martina McBride
- Episode 138 Eddie Izzard / Chris Botti
- Episode 139 Shirley Manson / Breckin Meyer
- Episode 140 John McEnroe / Stana Katic
- Episode 141 Kenneth Branagh / Antony and the Johnsons
- Episode 142 Michael Douglas / Carrie Ann Inaba Craig welcomes actor Michael Douglas and dance competition judge Carrie Ann Inaba.
- Episode 143 Henry Winkler / Ricky Hatton
- Episode 144 Jeffrey Dean Morgan / Stana Katic
- Episode 145 George Hamilton / Jenny Lewis
- Episode 146 Melina Kanakaredes / Nathan Fillion / Zac Brown Band
- Episode 147 Matthew McConaughey / Cokie Roberts
- Episode 148 Amy Smart / Kunal Nayyar
- Episode 149 Steven Wright / Bryce Dallas Howard Craig welcomes comedian Steven Wright and actress Bryce Dallas Howard. Henry Winkler appears as a 'personal budget expert'.
- Episode 150 Paulina Porizkova / Andy Nulman
- Episode 151 Laurence Fishburne / Paula Poundstone Craig welcomes actor Laurence Fishburne and comedienne Paula Poundstone, who also performs stand-up.
- Episode 152 Howie Mandel / Laura Lippman
- Episode 153 Ewan McGregor / All American Rejects
- Episode 154 Justin Long / Lawrence Block
- Episode 155 Kathy Griffin / Nelson George
- Episode 156 Guy Pearce / Hattie Hayridge
- Episode 157 John Waters / Manda Mosher
- Episode 158 Mark Ruffalo / Mindy Kaling / The Decemberists Craig welcomes actor Mark Ruffalo and actress Mindy Kaling. The Decemberists perform "Hazards of Love 2".
- Episode 159 Bob Saget / P. W. Singer
- Episode 160 Chris Isaac / Moon Bloodgood
- Episode 161 Mary-Louise Parker / Guillermo del Toro / Tori Amos
- Episode 162 Denis Leary / Diane Birch
- Episode 163 Jeffrey Tambor / Gabrielle Anwar
- Episode 164 Elizabeth Perkins / Mark Burnett / Bernie Williams
- Episode 165 Chris Kattan / Henry Cho
- Episode 166 Kevin Bacon / Michael Irvin
- Episode 167 Dame Edna Everage
- Episode 168 Chris Matthews / Theresa Andersson
- Episode 169 Larry King / Anna Friel
- Episode 170 Dane Cook / Peter Travers
- Episode 171 Holly Hunter / Camera Obscura
- Episode 172 Jeff Foxworthy / Gavin DeGraw
- Episode 173 Julia Ormond / Derrick Pitts
- Episode 174 Sandra Bullock / Metric / David Feldman
- Episode 175 Bryan Cranston / Ben Kweller
- Episode 176 Marion Cotillard / Michael Musto
- Episode 177 Jim Parsons / James Frey
- Episode 178 Mary Steenburgen / Bettye LaVette / Todd Sawyer
- Episode 179 Larry David / Wolfgang Puck
- Episode 180 Lisa Kudrow
- Episode 181 Eric Idle / Dr. Lisa Masterson Craig welcomes comedian Eric Idle.
- Episode 182 Evan Rachel Wood / Christopher Gorham Craig welcomes actress Evan Rachel Wood and actor Christopher Gorham.
- Episode 183 Julie Chen / Michael Ian Black / Will Dailey Craig welcomes TV host Julie Chen and comedian Michael Ian Black. With special guest "America's No. 1 Lifeguard" Henry Winkler.
- Episode 184 Jeff Goldblum / Jackie Collins
- Episode 185 Ray Romano / Michael Bublé
- Episode 186 Selma Blair / Connie Schultz
- Episode 187 John Larroquette / Will Dailey / Charlie Viracola
- Episode 188 Rosie Perez / Mike Massimino Craig welcomes actress Rosie Perez and astronaut Mike Massimino.
- Episode 189 Isaac Mizrahi / Shohreh Aghdashloo
- Episode 190 Paris Hilton / Alan Furst / Ray LaMontagne
- Episode 191 Margaret Cho / Michael Lewis / Eric Church
- Episode 192 Gerard Butler / Jackie Collins
- Episode 193 Tom Lennon / Kelly Rowland / Dobie Maxwell
- Episode 194 Cheryl Hines / Ben Mezrich
- Episode 195 Rashida Jones / José Andrés / Jim Breuer
- Episode 196 Chelsea Handler / Richard Wolffe
- Episode 197 Christiane Amanpour / Johnny Galecki
- Episode 198 Toni Collette / Rodney Carrington
- Episode 199 James Spader / Rose Byrne
- Episode 200 Saffron Burrows Craig welcomes actress Saffron Burrows.
- Episode 201 Edie Falco / Les Stroud / Lisa Landry
- Episode 202 Tony Shalhoub / Minka Kelly
- Episode 203 Wolf Blitzer / Rose Byrne
- Episode 204 Zooey Deschanel / Glasvegas
- Episode 205 Don Rickles / Sharon Jones & The Dap-Kings
- Episode 206 Carrot Top / Alexis Bledel
- Episode 207 Betty White / Mitch Albom / Bonnie Raitt & Taj Mahal
- Episode 208 Eric Bana / Holly Williams
- Episode 209 Jon Cryer
- Episode 210 Liza Minnelli / Kara Cooney