
- Episode 1 David Duchovny / Nicole Sullivan
- Episode 2 Jon Cryer / Sophie Okonedo / Keb’ Mo’
- Episode 3 Julian McMahon / Aisha Tyler / Howie Day
- Episode 4 Jason Alexander / Hau Thai-Tang / The Donnas
- Episode 5 Jeremy Piven / G. Love
- Episode 6 John Goodman / Emmy Rossum
- Episode 7 Little Richard / William H. Macy
- Episode 8 James Woods / Amanda Bynes / Jim Short
- Episode 9 Teri Polo / Eddie Steeples / Wyclef Jean
- Episode 10 Patricia Arquette / Peter Guber / Peter Bart
- Episode 11 Renée Fleming / Mos Def
- Episode 12 Regis Philbin / Rob Morrow / Billy Bragg
- Episode 13 Minnie Driver / Candace Bushnell
- Episode 14 Samuel L. Jackson / Maria Bello / Collective Soul
- Episode 15 Tara Reid / Crispin Glover / The Ditty Bops
- Episode 16 Jim Belushi / Kim Raver / DramaGods
- Episode 17 Famke Janssen / Joe Montana / Richard Jeni
- Episode 18 Blythe Danner / Stewart Francis
- Episode 19 Ice Cube / Steve Jones / French Kicks Craig welcomes actor Ice Cube and musician Steve Jones. French Kicks perform "The Trial Of The Century".
- Episode 20 Vanessa L. Williams / Scott Wolf / Razorlight
- Episode 21 Katey Sagal / Christine Barrett / Jake Shears / Scissor Sisters
- Episode 22 John Larroquette / Jennifer Finnigan / Rickey Smiley
- Episode 23 Joe Mantegna / Stan Lee / Emma Bunton
- Episode 24 Peter Gallagher / Laila Ali / …And You Will Know Us by the Trail of Dead
- Episode 25 Jeff Gordon / Philip Daniel Bolden / Andrew Donnelly
- Episode 26 Patti LaBelle / Imelda Staunton / Night Ranger
- Episode 27 Randy Jackson / Samantha Daniels / Greg Proops
- Episode 28 Laura Linney / Barry Watson / Laura Margolis / Kevin O’Connell
- Episode 29 Star Jones / Amber Valletta / The Zutons
- Episode 30 Alan Alda / Tori Spelling / Steve Earle
- Episode 31 Jane Seymour / Paul Haggis / Bright Eyes
- Episode 32 Mimi Rogers / James Denton / Courtney Hansen
- Episode 33 Jennifer Beals / David Krumholtz / Interpol
- Episode 34 Sean Astin / Kathryn Morris / Madeleine Peyroux
- Episode 35 Andy Dick / Julian Fellowes / Paul Gilmartin
- Episode 36 Bob Schieffer / John C. McGinley / Ani DiFranco
- Episode 37 Peter Boyle / Jenna Morasca / Ethan Zohn / Brian McKnight
- Episode 38 Thomas Haden Church / Don King / Maria Bamford
- Episode 39 Jami Gertz / Steven Wright / Sum 41
- Episode 40 Faye Dunaway / Andrew Wight / Nuttin’ But Stringz
- Episode 41 Amy Brenneman / Paul Westerberg
- Episode 42 Don Rickles / Missy Elliott / Judith Owen
- Episode 43 Jeff Probst / Emily Mortimer / Danny Bhoy
- Episode 44 Juliette Binoche / Lara Logan / Stanley Bing
- Episode 45 Jennifer Love Hewitt / Dave Foley / Ali Costello / Unwritten Law
- Episode 46 Joan Collins / Phil Keoghan / The Blue Nile
- Episode 47 Drew Carey / Lawrence Block / The Hollow Men
- Episode 48 Kevin Pollak / Maureen Dowd / Deana Carter
- Episode 49 Michael Chiklis / Tony Hawk / Nic Armstrong & The Thieves
- Episode 50 Sam Elliott / Amy Yasbeck / Bob Marley
- Episode 51 Andie MacDowell / Gerard Butler / Kathleen Edwards
- Episode 52 Wendie Malick / Chris Klug / Lisa Loeb
- Episode 53 Robert Rodriguez / Stone Cold Steve Austin / k-os
- Episode 54 Carmen Electra / Nick Stahl / Lang Lang
- Episode 55 Bernie Mac / Mädchen Amick / Rachael Scdoris
- Episode 56 Carla Gugino / Regina King / Elon Gold
- Episode 57 Jimmy Smits / Moby
- Episode 58 Michael Clarke Duncan / Mary McCormack / Becky Pedigo
- Episode 59 Ron Livingston / Dave Gorman / Jesse McCartney
- Episode 60 Amber Tamblyn / Jason Lee / Steven Hensley
- Episode 61 Eric Idle / Rulon Gardner / Mike Birbiglia
- Episode 62 Sara Rue / Matthew Polly / Aqualung
- Episode 63 Fran Drescher / Anton Yelchin / Shooter Jennings
- Episode 64 David Duchovny / Ryan Reynolds / Dinosaur Jr.
- Episode 65 Suzanne Somers / Erykah Badu / Billy Miles
- Episode 66 Thandie Newton / Barb MacLeod
- Episode 67 Paul Haggis / Michael Gelbart / Gavin Rossdale
- Episode 68 Rosie O’Donnell / Akiane Kramarik
- Episode 69 Anjelica Huston / Danny Pino / The Futureheads
- Episode 70 Jonathan Rhys Meyers / Ben Stein / Kasabian
- Episode 71 Bill Maher / Rain Pryor / Stewart Francis
- Episode 72 Gary Sinise / Dean Karnazes / Ben Folds
- Episode 73 Ozzy Osbourne / Allison DuBois / Brendan Benson
- Episode 74 Jim Caviezel / Phil Lesh / Eels
- Episode 75 Mark Harmon / RZA / Joss Stone
- Episode 76 Rose McGowan / Sanjay Gupta / Charlie Daniels
- Episode 77 Kermit the Frog / Leelee Sobieski / Tori Amos
- Episode 78 Bill Pullman / Ruth Reichl / Spoon
- Episode 79 Wanda Sykes / Eric Bogosian
- Episode 80 Mike Huckabee / Marlee Matlin / John Butler Trio
- Episode 81 Joe Walsh / George Eads / Junior Brown
- Episode 82 Sela Ward / Michael Tucker / Acceptance
- Episode 83 Phil McGraw / Ringside
- Episode 84 Randy Jackson / Bai Ling / Gary Greff
- Episode 85 Ann Coulter / Amber Mariano / Rob Mariano / Charles Ross
- Episode 86 Alice Cooper / Malachy McCourt / Dierks Bentley
- Episode 87 Donny Osmond / Peter Bart / Robert Cray
- Episode 88 Rachael Leigh Cook / Chuck Palahniuk / Layzie Bone
- Episode 89 Seth Green / Tony Alva / The Daylights
- Episode 90 Jon Cryer / Garrison Keillor / Sound of Urchin
- Episode 91 Marg Helgenberger / David Milch / Jaguares
- Episode 92 Dennis Hopper / Marianne Jean-Baptiste / Carlos Alazraqui
- Episode 93 Ricky Schroder / Toby Keith
- Episode 94 Vivica A. Fox / Poppy Montgomery / Angie Stone
- Episode 95 Jason Lee / Drew Pinsky / Midlake
- Episode 96 Cheryl Ladd / Skeet Ulrich / Kaiser Chiefs
- Episode 97 Steven Wright / John F. Banzhaf III / Amos Lee
- Episode 98 Tommy Hilfiger / Lea Thompson / Nikka Costa
- Episode 99 Debbie Reynolds / Thomas Lennon / Nick Hornby
- Episode 100 Allison Janney / Julian Sands / Rilo Kiley
- Episode 101 Peter Krause / David LaChapelle / Tracy Bonham
- Episode 102 John Waters / Loretta Devine / Demetri Martin
- Episode 103 Mimi Rogers / James Ellroy / Brooke Valentine
- Episode 104 Jeremy Piven / Melissa Bank / Mike Jones
- Episode 105 Bryan Cranston / Peter Guber / The Krumpers
- Episode 106 Amy Yasbeck / Ringo Starr
- Episode 107 Kara Cooney / Dwight Yoakam
- Episode 108 Jennifer Tilly / Corbin Bernsen / Leroy Chiao
- Episode 109 Tom Bergeron / Greg Nicotero / Billy Bragg
- Episode 110 Julian McMahon / Rachel DeWoskin / The Crystal Method
- Episode 111 Dave Navarro / Marisa Marchetto / Ron Pearson
- Episode 112 Tony Shalhoub / Jared Diamond / Raul Midón
- Episode 113 Beau Bridges / Harry Eden / Martha Kelly
- Episode 114 John Larroquette / Dan Huber / Fountains of Wayne
- Episode 115 Wolf Blitzer / Karina Lombard / Nellie McKay
- Episode 116 Ludacris / Julie Warner / Ty Barnett
- Episode 117 Dave Foley / Marc Horowitz / T-Boz & Chilli
- Episode 118 Warren Faidley / Martin Mull / Preston Clarke
- Episode 119 Camryn Manheim / Elizabeth Banks / Crossfade
- Episode 120 Eddie Izzard / R. James Woolsey Jr. / Elkland
- Episode 121 Peter Arnett / Isla Fisher / Wendy Liebman
- Episode 122 Joe Buck / Pauley Perrette
- Episode 123 Dermot Mulroney / Paul Feig
- Episode 124 Cloris Leachman / Mark Zupan / Carlos Mencia
- Episode 125 Jane Kaczmarek / John Carroll Lynch / Greg Proops
- Episode 126 Joseph Fiennes / Julie Chen / Tracy Bonham
- Episode 127 Sharon Stone / Mo’Nique
- Episode 128 Buzz Aldrin / Method Man / John Mendoza
- Episode 129 Marilu Henner / David Feherty
- Episode 130 Harland Williams / Evan Rachel Wood / Babyface
- Episode 131 Kristin Chenoweth / Marc Cherry / Natasha Bedingfield
- Episode 132 Hank Azaria / Wes Craven
- Episode 133 Rachel Griffiths / Tommy Lasorda / D. C. Benny
- Episode 134 Arianna Huffington / Gigi Grazer / Louis CK
- Episode 135 Jami Gertz / Steve Howey / Missy Higgins
- Episode 136 Steve Carell / Rashida Jones / Rick Lundblade
- Episode 137 Carl Reiner / Rosa Blasi / Rufus Wainwright
- Episode 138 Minnie Driver / Todd Zeile
- Episode 139 Eric McCormack / Mitch Albom
- Episode 140 Carrie Fisher / Terry McDermott / Our Lady Peace
- Episode 141 Felicity Huffman / Stanley Bing / Last Train Home